Feels to me that the last part of the conversation is not about Wiley anymore, but about the relationship between Michelle and Peter. Basicly, that she is in love with him and she wishes he would be available and reciprocate.
Shit... Michelle wants Peter. That third panel totally reminded me of Éowyn's line in Lord of the Rings when she confesses her love to Aragorn. Yep, that's how geeky I am.
I saw a few hints of that, what with their seemingly exclusive conversation at that party on Bishop Street way back, her reaction to Kara's suggestion of a threesome, and the fact that Peter has never judged her...
Man, Ol' Slugger's got animal magnetism oozing out of every pore and he don't even know it! I mean, christ... He's got Kara, Vivian's bra, an open invite from that concert chick, and now possibly Michelle. The ladies sure wuv'im! :P
I guess being a stand-up, no-bullshit guy pays off after all.
Then again, maybe I'm way off base here, but this is my gut instinct.
I'm pretty sure this is about to be "Wiley has serious mental health issues and is on medication." I get the feeling while she calls him little brother and is super protective of him it's because of his imbalance.
Just my thoughts. Pretty sure Michelle wants that Slugger action though.
EDIT: Just re-read the panel and she says "Do you really NOT know?" I thought it said "Do you really want to know?" which threw me off. It's about to get awkward romantic sexual tension up in this.